Implementation of a fixed-dose strategy of 4-factor prothrombin complex concentrate for warfarin reversal Slaughter, William S; Leos, Cara L; Wheeler, Samantha N Baptist Medical Center South - Montgomery, AL
Background/Purpose: Implement a fixed-dose protocol for the use of 4-factor prothrombin complex concentrate (4FPCC) when treating warfarin-related life-threatening bleeding.
Methodology: After January 1st, 2019, all patients ages 19 and older prescribed 4FPCC for the treatment of warfarin-related bleeding were dosed according to a fixed-dose strategy of 2000 units. The pharmacist then ensured a pre-dose INR measurement had been drawn in addition to a follow-up INR measurement timed 60 minutes after order verification. To accompany the 4FPCC, the pharmacist also ensured a one-time order for intravenous Vitamin K 10mg. Data were compared to historical patients to assess INR response, total 4FPCC product use, and time from order to administration.
Presentation Objective: Discuss the benefits of a fixed-dose protocol for the ordering and administration of 4FPCC.
Self-Assessment: What is one potential benefit for using a fixed-dose strategy of 4FPCC for life-threatening bleeding?
